Table 1.

Genes in the signaling transduction pathway up-regulated in A. actinomycetemcomitans infected OBA-9 gingival epithelial cells, in comparison with non infected control cells. Student’s t-test, significant difference in gene expression was considered when p<0.01.

Symbol	Pathway	Gene	Gen Bank	Fold Changes	p-value
BIRC3	NF-κB	Baculoviral IAP repeat-containing 3	NM_001165	5.92	0.000022
CCL2	LDL	Chemokine (C-C motif) ligand 2	NM_002982	12.18	0.000003
CCL20	NF-κB	Chemokine (C-C motif) ligand 20	NM_004591	6.49	0.0012
CDKN1A	TGF-β/p53/Androgen	Cyclin-dependent kinase inhibitor 1A	NM_000389	4.88	0.0015
CSF2	LDL/calcium and protein quinase C/NF-κB (Zhang et al., 2011)	Colony stimulating factor 2	NM_000758	170.04	0.00002
EGR1	Mitogenic/CREB/PhospholipaseC	Early growth response 1	NM_001964	14.08	0.00066
FOS	Mitogenic/Stress/PhospholipaseC/JNK/p38 (Zhang et al., 2011)	V-fos FBJ murine osteosarcoma viral oncogene homolog	NM_005252	4.47	0.004
GADD45A	p53/Stress/DNA repair/cell cycle arrest (Zhang et al., 1999)	Growth arrest and DNA-damage- inducible, alpha	NM_001924	8.00	0.00058
GREB1	Estrogen	GREB-1 protein	NM_014668	10.13	0.0088
ICAM1	NF-κB/Phospholipase C	Intercellular adhesion molecule 1 (CD54), human rhiono virus receptor	NM_000201	7.67	0.00003
IL1A	NF-κB	Interleukin 1, alpha	NM_000575	4.01	0.0009
IRF1	JAK-STAT/IRF (Zhang et al., 2011)	Interferon regulatory factor 1	NM_002198	5.39	0.004
JUN	Mitogenic/WNT/PI3 kinase-AKT/Calcium and protein kinase C/PhospholipaseC JNK/p38 (Zhang et al., 2011)	Jun oncogene	NM_002228	7.16	0.00023
TNF	NF-κB	Tumor necrosis factor (TNF superfamily, member 2)	NM_000594	28.93	0.0097
VEGFA	WNT	Vascular endothelial growth factor A	NM_003376	4.59	0.000246