Table 2.

Influence of isoflavones on the secretion of various inflammatory markers in cell lines.

Compounds	Cell line	Downregulated pro-inflammatory mediators	Upregulated anti-inflammatory mediators	Ref.
genistein, equol	RAW 264.7	NO, PGE2		[136]
genistein,	RAW 264.7	TNFα, IL-6, iNOS, NFκB	IL-10	[114]
daidzein,		TNFα, IL-6, iNOS, NFκB
formononetin		iNOS
biochanin A		TNFα, IL-6, iNOS, NFκB, Cox-2	IL-10
equol		TNFα, IL-6, COX-2
ODMA		TNFα, IL-6
genistein	HBMEC	TNFα, IL-1β, monocyte chemoattractant protein-1, IL-8, intercellular adhesion molecule-1		[137]
genistein, daidzein	murine J774 macrophages	iNOS, NO		[138]
genistein	Human chondrocytes	COX-2, NO		[139]
biochanin A	MC3T3-E1 cells	TNFα, IL-6, NO		[140]
genistein	PBLs	TNFα, IL-8		[141]
genistein	mesencephalic neuron-glia cultures	TNFα, NO, superoxide		[142]
daidzein, formononetin	mesencephalic neuron-glia cultures	TNFα, NO, superoxide		[143]
biochanin A	mesencephalic neuron-glia cultures	TNFα, NO, superoxide		[144]
genistein	alveolar macrophages	TNFα		[145]
daidzein	PBMC	higher concentrations reduced IL-10 and IFN-γ levels	low concentration increased IL-2, IL-4,and IFN-γ	[146]
genistein		IL-2, IL-4, IL-10, IFN-γ mRNA and protein
genistein	RAW 264.7	NO, PGE2		[147]
genistein	RAW 264.7	PGE2, iNOS, COX-2		[148]
genistein, daidzein, glycetein	RAW 264.7	NO, iNOS		[149]
genistein, daidzein, equol	MCF-7 cells	COX-2		[150]

HBMEC (human brain microvascular endothelial cells); MC3T3-E1 (osteoblasts); MCF-7 (human breast cancer cell line); PBL (human peripheral blood mononuclear and/or polymorphonuclear leukocytes); PBMC (peripheral blood mononuclear cells); RAW 264.7 (mouse macrophage).