Table 3.
Intervention with vitamin D analogues (with / without calcium) on fracture incidence.
| Study | Study design | n | Sex | Mean age (years) | Treatment | Length | Results |
|---|---|---|---|---|---|---|---|
| CT, controlled trial; F, female; M, male; Cl, Calcitriol; Ac, Alfacalcidol; Ca, Calcium; /d, daily; wkly, weekly; yr, year;yrs, years | |||||||
| Vitamin D analogues | |||||||
| Hayashi et al. 1992 (67) | CT | 740 | M/F | 75 | 40 IU Ac/d | 1 yr | Lower fracture incidence |
| Tyliard et al. 1992 (68) | CT | 622 | F | 63 | 20 IU Cl/d | 3 yrs | Reduction in vertebral fractures |
| Sato et al. 1999 (70) | CT | 86 | M/F | 70 | 40 IU Ac/d | 2 yrs | 17.5% lower fracture rate |
| Ebeling et al. 2001 (72) | CT | 41 | M | 57.5 | 20 IU Cl/d | 2 yrs | No effect |
| Gallagher et al. 2001 (73) | CT | 489 | F | 72 | 20 IU Cl/d | 2 yrs | No effect |
| Vitamin D analogues with calcium | |||||||
| Orimo et al. 1994 (82) | CT | 80 | F | 70 | 40 IU Ac & 300mg Ca/d | 1 yr | Decreased vertebral fracture incidence |
| Shikari et al. 1996 (83) | CT | 113 | F | 70 | 30 IU Ac & 300mg Ca/d | 2 yrs | Decreased incidence of fractures |
| Stempfle et al. 1999 (86) | CT | 132 | M/F | 50 | 10 IU Cl & 1000mg Ca/d | 3 yrs | No effect |