Table 7.
Intervention with vitamin D or vitamin D analogues (with / without calcium) on falls.
| Study | Study design | n | Sex | Mean age (years) | Treatment | Duration | Results |
|---|---|---|---|---|---|---|---|
| CT, controlled trial; F, female; M, male; D3, cholecalciferol; D2, ergocalciferol;Ac, Alfacalcidol /d, daily; wkly, weekly; Ca, calcium;*changed to 1000 IU D2 daily with 600 mg calcium | |||||||
| DawsonHughes et al. 1997 (84) | CT | 389 | M/F | >65 | 700 IU D3/ 500 mg Ca/d | 3 yrs | No effect on falls |
| Pfeifer et al. 2000(144) | CT | 148 | F | 70-86 | 800 IU D3/1,200 mg Ca/d | 2 mths | Reduced body sway (9%) and 1 yr follow up lower number of falls |
| Chapuy et al. 2002 (87) | CT | 583 | F | 85 | 800IU D3/1200 mg Ca/d | 2 yrs | No effects on falls |
| Larsen et al. 2002 (89) | IT | 5771 | F | 74 | 400 IU D3/1000 mg Ca/d | 3.5yrs | Reduced risk of severe falling by 12% |
| Bischoff et al. 2003 (145) | CT | 122 | F | >65 | 800IU D3/1200 mg Ca/d | 12 wks | 49% reduction in falling and improved muscoskeletal function |
| Dukas et al. 2004(146) | CT | 378 | M/F | 75 | 40 IU Ac/d | 9 mths | Reduction in falls only with Ca intake >512 mg/d in addition |
| Flicker et al. 2005 (147) | CT | 625 | M/F | 83 | 10,000 IU D2/wkly* | 2 yrs | Reduction in incidence ratio for falls |
| Bischoff et al. 2006 (148) | CT | 445 | M/F | >65 | 700 IU D3/500 mg Ca/d | 3 yrs | 46% reduction falls in womem (65% reduction in non-active women) |
| Pfeifer et al. 2009 (149) | CT | 242 | M/F | >70 | 800 IU D3/1000mg Ca/d | 18 mths | 27% reduction in falls & 28% decrease in body sway |