Table 1.

ACE inhibitory peptides from meat of domestic animals. Adapted with permission from American Chemical Society [3], Copyright 2005.

Source	Amino Acid Sequence	Parent Protein	Enzyme	IC50 (µM)	SHR a	Ref.
pig	ITTNP	myosin	thermolysin	549	∆ 21.0 mmHg	[23,66]
	MNPPK	myosin	synthesized	945.5	∆ 23.4 mmHg	[23,66]
	MNP	myosin	synthesized	66.6	∆ 19.6 mmHg	[23,66]
	PPL	myosin	synthesized	>1000	∆ 24.7 mmHg	[23,66]
	NPP	myosin	synthesized	290.5	∆ 17.6 mmHg	[23,66]
	TNP	myosin	synthesized	207.4	∆ 11.1 mmHg	[23,66]
	RMLGQTPTK	troponin	pepsin	34	nt	[50,85]
	RMLGQTP	troponin	pepsin	503	nt	[50]
	VKKVLGNP	myosin	pepsin	28.5	∆ 24.0 mmHg b	[84]
	KRVITY	myosin	pepsin	6.1	∆ 23.0 mmHg b	[83]
	VKAGF	actin	pepsin	20.3	∆ 17.0 mmHg b	[83]
	KRQKYDI	troponin T	pepsin	26.2	∆ 9.9 mmHg b	[24]
	KAPVA	titin	pepsin + pancreatin	46.56	nt	[86]
	PTPVP	titin	pepsin + pancreatin	256.41	nt	[86]
	ER	muscle	pepsin + pancreatin	667	nt	[86]
	KLP	muscle	pepsin + pancreatin	500	nt	[86]
	RPR	muscle	pepsin + pancreatin	382	nt	[86]
chicken	LKA	creatine kinase	thermolysin	8.5	nt	[89]
	LKP	aldolase	thermolysin	0.32	∆ 75 mmHg c	[89]
	LAP	muscle	thermolysin	3.2	∆ 40.0 mmHg c	[89]
	FQKPKR	myosin	thermolysin	14	nt	[89]
	FKGRYYP	creatine kinase	thermolysin	0.55	∆ 0 mmHg c	[89]
	IKW	muscle	thermolysin	0.21	∆ 50.0 mmHg c	[89]
	GFXGTXGLXGF	muscle	Aspergillus protease + gastric proteases	42.4	∆ 20 mmHg d	[36,79]
	GAXGLXGP	collagen	Aspergillus protease + protease FP, A, G, N	29.4	nt	[37]
	GAXGPAGPGGIXGERGLXG	collagen	Aspergillus protease + protease FP, A, G, N	45.6	nt	[37]
	GLXGSRGERGERGLXG	collagen	Aspergillus protease + protease FP, A, G, N	60.8	nt	[37]
	GIXGSRGERGPVGPSG	collagen	Aspergillus protease + protease FP, A, G, N	43.4	nt	[37]
cow	VLAQYK	muscle	thermolysin + proteinase A	32.06	+	[25,88]
	GFHI	muscle	proteinase K	64.3	nt	[10]
	DFHING	muscle	alcalase	50.5	nt	[10]
	FHG	muscle	thermolysin + proteinase A	52.9	nt	[10]
	GLSDGEWQ	muscle	thermolysin + proteinase A	117	nt	[10]
	GPV	skin gelatin	alcalase + pronase E + collagenase	4.67	nt	[34]
	GPL	skin gelatin	alcalase + pronase E + collagenase	2.55	nt	[34]

^a The maximum decrease in systolic blood pressure in SHR upon oral administration of peptide at 1 mg/kg; ^b The maximum decrease in systolic blood pressure in SHR upon oral administration of peptide at 10 mg/kg; ^c The maximum decrease in systolic blood pressure in SHR upon intravenous administration of peptide at 10 mg/kg; ^d The maximum decrease in systolic blood pressure in SHR upon intravenous administration of peptide at 30 mg/kg; nt: Not tested in spontaneously hypertensive rats.