Table 3.
Summary of Log-Linear Modeling Results for the Combined CTD and LSL Case-Parents Triads.
| MTHFR A1298C (1801131)a 481/168/20b |
MTHFR C677T (1801133) 487/165/18 |
MTRR A66G (1801394) 461/183/25 |
MCP1 A2518G (1024611) 477/172/19 |
BHMT G742A (3733890) 481/172/17 |
TCN2 C777G (1801198) 473/165/30 |
SHMT C1420T (1979277) 479/172/18 |
NOS3 G894T (179983) 469/179/19 |
|
|---|---|---|---|---|---|---|---|---|
| R1c (95% CI) | 0.84 (0.68–1.04) | 1.22 (0.98–1.52) | 0.84 (0.64–1.09) | 1.02 (0.82–1.27) | 0.96 (0.77–1.19) | 0.77 (0.62–0.97) | 1.12 (0.9–1.4) | 1.03 (0.83–1.29) |
| R2 (95% CI) | 0.91 (0.63–1.33) | 1.17 (0.82–1.66) | 0.79 (0.56–1.09) | 1.05 (0.68–1.61) | 0.86 (0.58–1.28) | 0.73 (0.52–1.02) | 1.22 (0.83–1.79) | 0.96 (0.65–1.41) |
| S1d (95% CI) | 1.04 (0.82–1.31) | 1.15 (0.90–1.47) | 1.23 (0.90–1.69) | 0.99 (0.78–1.27) | 0.81 (0.64–1.04) | 1.17 (0.91–1.51) | 0.84 (0.66–1.08) | 1.26 (0.98–1.63) |
| S2 (95% CI) | 0.83 (0.55–1.27) | 1.46 (1.01–2.12) | 1.17 (0.84–1.64) | 0.89 (0.55–1.44) | 0.84 (0.55–1.28) | 0.99 (0.71–1.37) | 0.67 (0.43–1.05) | 1.43 (0.94–2.20) |
| LRT for offspring effects (p-value) | 2.59 (0.27) | 3.23 (0.20) | 2.24 (0.33) | 0.05 (0.97) | 0.56 (0.76) | 5.35 (0.07) | 1.43 (0.49) | 0.23 (0.89) |
| LRT for maternal effects (p-value) | 0.97 (0.61) | 4.34 (0.11) | 1.66 (0.44) | 0.23 (0.89) | 2.97 (0.23) | 1.92 (0.38) | 3.99 (0.14) | 4.77 (0.09) |
a
dbSNP rs#
b
Number of triads with genotype data for 3, 2 or 1 member.
c
R1 and R2 denote the relative risk to cases with the heterozygous and rare homozygous genotypes, respectively, as compared to cases with the common homozygous genotype.
d
S1 and S2 denote the relative risk to offspring of women with the heterozygous and rare homozygous genotypes, respectively, as compared to the common homozygous genotype.