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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Semin Hematol. 2012 Jan;49(1):83–93. doi: 10.1053/j.seminhematol.2011.10.002

Table 1.

Risk Factors and Timing of Ovarian Failure after Hematopoietic stem cell transplantation (HSCT)

Risk factors
Transient ovarian failure in the two years after HSCT
 •Endocrine disruption  •Adrenal Insufficiency, transient hypo- or hyperthyroidism
 •Immunosuppression  •High dose steroids
 •Chronic disease  •Severe infection or chronic graft-versus-host disease
Long-term ovarian failure*
 •Pubertal Status  •After puberty
 •Age at first treatment  •Older age
 • Underlying disease, tendency to infiltrate ovaries  •Lymphoma, acute lymphocytic leukemia
 •Type of transplant  •Allogeneic
 •Number of HSCT  •Two or more
 •Conditioning regimen  •Myelo-ablative
 •Chemotherapy regimen  •Chemotherapy prior to transplant
 •Alkylating agents
 •Multiple alkylating agents
 •Radiation  •High dose
 • Multiple doses
 • Pelvic or total body
 •Graft-versus-host disease  • Long-term Immunosuppression
*

Premature menopause – age <40 years has these same risk factors