Table II.
Adjusted HRs of Incident Heart Failure in Relation to Markers of Inflammation (N=3098)
| Incident Heart Failure HR (95% CI) per SD Log Increasea,b | P Valuea,b | |
|---|---|---|
| CRP | ||
| Age‐ and sex‐adjusted model | 1.25 (1.09–1.44) | .001 |
| Multivariate modelc | 1.13 (0.97–1.32) | .124 |
| Fibrinogen | ||
| Age‐ and sex‐adjustedmodel | 1.60 (1.39–1.86) | <.001 |
| Multivariate modelc | 1.36 (1.15–1.59) | <.001 |
| Odds Ratio (95% CI) per SD Log Increasea,d | P Valuea,d | |
| MPOd (N=166) | ||
| Age‐ and sex‐matched | 1.04 (0.78–1.37) | .800 |
| Multivariate modelc | 1.01 (0.68–1.51) | .961 |
Abbreviations: CI, confidence interval; HR, hazard ratio. aRespective values for standard deviations (SDs) were fibrinogen=0.226 mg/dL, C‐reactive protein (CRP)=0.987 mg/dL, and myeloperoxidase (MPO)=0.586 pmol/L. All the biomarkers were log‐transformed to achieve normality. bCox proportional models were used to analyze the associations between CRP/fibrinogen and HF. cAdjusted for age, sex, body mass index, hypertension, low‐density lipoprotein cholesterol, diabetes, smoking, and estimated glomerular filtration rate. dConditional logistic regression was used to assess the association between the MPO level and incident heart failure.