Table 1.
Regulation of Runx1 expression by Fgf, Wnt and Notch signaling
| Injection | Probe | N | Normal | Reduced/Lost | Expanded/Ectopic |
|---|---|---|---|---|---|
| Fgf8a | Runx1 Ngnr1 N-Tub |
52 57 45 |
0% 2% 9% |
0% 2% 7% |
100% 96% 84% |
| Fgf8MO | Runx1 Ngnr1 N-Tub |
76 47 43 |
15% 34% 10% |
84% 66% 88% |
1% 0% 2% |
| Wnt8MO | Runx1 Ngnr1 N-Tub |
51 53 52 |
4% 11% 2% |
96% 89% 98% |
0% 0% 0% |
| β-CatMO | Runx1 Ngnr1 N-Tub |
32 26 29 |
0% 0% 0% |
100% 100% 100% |
0% 0% 0% |
| Notch ICD | Runx1 Ngnr1 N-Tub |
37 33 42 |
0% 6% 0% |
100% 73% 100% |
0% 21% 0% |