Table 1.
A549 | Chrysin (μM) | H157 | Chrysin (μM) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dox | 0 | 5 | 10 | 15 | 20 | 25 | 30 | Dox | 0 | 5 | 10 | 15 | 20 | 25 | 30 |
IC10 | 0.042 | 0.041 | 0.040 | 0.031 | 0.029 | 0.018 | 0.017 | IC10 | 0.065 | 0.075 | 0.095 | 0.072 | 0.091 | 0.062 | 0.075 |
IC20 | 0.093 | 0.085 | 0.081 | 0.062 | 0.061 | 0.046 | 0.045 | IC20 | 0.147 | 0.135 | 0.153 | 0.124 | 0.150 | 0.114 | 0.132 |
IC30 | 0.158 | 0.137 | 0.128 | 0.100 | 0.099 | 0.085 | 0.086 | IC30 | 0.253 | 0.199 | 0.212 | 0.179 | 0.209 | 0.171 | 0.193 |
IC40 | 0.245 | 0.203 | 0.187 | 0.147 | 0.147 | 0.140 | 0.146 | IC40 | 0.393 | 0.274 | 0.275 | 0.241 | 0.247 | 0.239 | 0.264 |
IC50 | 0.365 | 0.291 | 0.264 | 0.210 | 0.212 | 0.223 | 0.238 | IC50 | 0.589 | 0.367 | 0.350 | 0.317 | 0.351 | 0.325 | 0.351 |
IC60 | 0.543 | 0.418 | 0.374 | 0.300 | 0.306 | 0.354 | 0.388 | IC60 | 0.884 | 0.492 | 0.446 | 0.417 | 0.451 | 0.442 | 0.467 |
IC70 | 0.839 | 0.620 | 0.545 | 0.441 | 0.456 | 0.587 | 0.661 | IC70 | 1.38 | 0.678 | 0.581 | 0.562 | 0.591 | 0.671 | 0.638 |
IC80 | 1.43 | 1.00 | 0.864 | 0.707 | 0.742 | 1.087 | 1.267 | IC80 | 2.36 | 1.00 | 0.801 | 0.809 | 0.823 | 0.928 | 0.932 |
| |||||||||||||||
H460 | Chrysin (μM) | H1975 | Chrysin (μM) | ||||||||||||
| |||||||||||||||
Dox | 0 | 5 | 10 | 15 | 20 | 25 | 30 | Dox | 0 | 5 | 10 | 15 | 20 | 25 | 30 |
| |||||||||||||||
IC10 | 0.012 | 0.010 | 0.011 | 0.013 | 0.014 | 0.004 | 0.003 | IC10 | 0.014 | 0.018 | 0.017 | 0.013 | 0.013 | 0.014 | 0.015 |
IC20 | 0.022 | 0.016 | 0.017 | 0.017 | 0.020 | 0.007 | 0.006 | IC20 | 0.025 | 0.024 | 0.023 | 0.017 | 0.019 | 0.019 | 0.020 |
IC30 | 0.034 | 0.021 | 0.023 | 0.021 | 0.024 | 0.009 | 0.008 | IC30 | 0.036 | 0.030 | 0.029 | 0.021 | 0.024 | 0.024 | 0.025 |
IC40 | 0.049 | 0.026 | 0.028 | 0.025 | 0.029 | 0.013 | 0.011 | IC40 | 0.050 | 0.036 | 0.035 | 0.024 | 0.029 | 0.028 | 0.030 |
IC50 | 0.067 | 0.033 | 0.035 | 0.030 | 0.033 | 0.016 | 0.015 | IC50 | 0.066 | 0.042 | 0.042 | 0.028 | 0.034 | 0.034 | 0.035 |
IC60 | 0.042 | 0.035 | 0.039 | 0.020 | 0.020 | 0.020 | 0.020 | IC60 | 0.087 | 0.049 | 0.050 | 0.033 | 0.041 | 0.040 | 0.041 |
IC70 | 0.133 | 0.052 | 0.053 | 0.042 | 0.046 | 0.026 | 0.027 | IC70 | 0.119 | 0.058 | 0.060 | 0.038 | 0.050 | 0.047 | 0.049 |
IC80 | 0.205 | 0.070 | 0.070 | 0.051 | 0.056 | 0.036 | 0.039 | IC80 | 0.173 | 0.072 | 0.076 | 0.047 | 0.063 | 0.059 | 0.061 |
Chrysin significantly sensitized all four cell lines to DOX treatment as compared to DOX alone treated cells (column 0 in each cell type box). IC50 values were determined using Prizm and calculated from the dose response curves.