Figure 1.

Pedigrees of Four Unrelated Families with Deletions at the NRXN3 Locus

Black-filled symbols represent ASD-affected individuals, gray-filled symbols represent broader autism phenotype (BAP)-affected individuals, and unfilled symbols represent apparently unaffected individuals. Probands are marked with an arrow. Clinical diagnosis and segregation of the NRXN3 deletions are shown. Children are placed left to right in birth order from eldest to youngest. Other CNVs and genetic variants are found in Tables S1, S2, and S4–S7. Abbreviations are as follows: ADHD, attention deficit hyperactivity disorder; OCD, obsessive compulsive disorder; and NA, not assessed.