Fig. 5.

Rhodopsin-like GPCRs involved in the A. gambiae response to Plasmodium invasion. (A) Expression heat maps showing differential expression of rhodopsin-like GPCR-encoding genes upon invasion of the A. gambiae midgut by P. falciparum or P. berghei. Yellow and blue indicate upregulation and downregulation, respectively. Different color intensities represent different levels of regulation. Indep., independent of infection intensity; High or Low, high- or low-intensity infection. (B) Predicted protein domain structures of GPCR-encoding genes selected for phenotypic characterization. GRPCCK1 is predicted to encode two isoforms via alternative splicing (RA and RB).