Fig. 6.

Effect of A. gambiae rhodopsin-like GPCR silencing on Plasmodium infection. The numbers of oocysts in the midguts of A. gambiae mosquitoes with GPCR knockdown, infected with P. falciparum (Pf) (red) or P. berghei (Pb) (green), were plotted against the numbers of oocysts in corresponding lacZ dsRNA-injected controls (gray). Data were analyzed either independently of infection intensity (A) or after grouping of infections into high- or low-intensity infections (B) as assessed in lacZ dsRNA-injected controls. Infection intensity analyses were possible only for P. falciparum. Arithmetic means (red horizontal lines) and standard errors (error bars) of pooled data from replicate experiments (n) are shown. The total number of midguts (N) in each data set is given at the bottom. P values for the meta-analysis are indicated above each data set as follows: *, P < 0.05; **, P < 0.01; ***, P < 0.001.