Table 1.
Summary of 12 human proteins that interact with E. chaffeensis TRP120 determined by yeast two-hybrid assay and cotransformation
| Interacting human proteina | GenBank accession no. | Properties/functions |
|---|---|---|
| Immunoglobulin lambda locus (IGL) | XM_002348112.1 | Recognizes foreign antigens and initiates immune responses such as phagocytosis and the complement system |
| Cytochrome c oxidase subunit II (COX2) | XR_078889.1 | Terminal enzyme of the mitochondrial respiratory chain, catalyzing the transfer of electrons from reduced cytochrome c to molecular oxygen |
| Immunoglobulin kappa constant (IGKC) | NW_001838785.1 | Recognizes foreign antigens and initiates immune responses such as phagocytosis and the complement system |
| Immunoglobulin heavy constant alpha 1 (IGHA1) | NW_001838121.1 | Recognizes foreign antigens and initiates immune responses such as phagocytosis and the complement system |
| Erythrocyte membrane protein band 4.2 (EPB42) | NM_001114134.1 | An ATP-binding protein which may regulate the association of protein 3 with ankyrin; it probably has a role in erythrocyte shape and mechanical property regulation |
| Golgi-associated, gamma adaptin ear-containing, ARF binding protein 1 (GGA1) | NM_013365.3 | Ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome |
| Prosaposin (PSAP) | NM_001042466.1 | A highly conserved glycoprotein which is a precursor for saposins; saposins localize primarily to the lysosomal compartment, where they facilitate the catabolism of glycosphingolipids |
| Solute carrier family 2, member 3 (SLC2A3) | NM_006931.2 | Glucose transmembrane transporter |
| unc-13 homolog D (C. elegans) (UNC13D) | NM_199242.2 | A member of the UNC13 family that appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion |
| Polycomb group ring finger 5 (PCGF5) | NM_032373.3 | DNA-dependent regulation of transcription, metal ion binding, and protein binding |
| Actin, gamma 1 (ACTG1) | NM_001614.2 | A cytoplasmic actin found in nonmuscle cells; highly conserved proteins that are involved in various types of cell motility and maintenance of the cytoskeleton |
| F-box and WD repeat domain containing 7 (FBXW7) | NT_016354.19 | The F-box proteins constitute one subunit of ubiquitin protein ligase complex SCFs (SKP1 [S-phase KimSC-associated protein 1] cullin-F-box) which function in phosphorylation-dependent ubiquitination; seven tandem WD40 repeats bind directly to cyclin E, probably for ubiquitin-mediated degradation |
a
Listed by the order of identification frequency.