Fig. 6.

Time course of expression of the chemokines MIP-1α/CCL3 and IP-10/CXCL10 in tissues after infection with virulent L. interrogans serovar Icterohaemorrhagiae strain Verdun. Quantification of MIP-1α/CCL3 (A) and IP-10/CXCL10 (B) mRNA in blood, liver, kidneys, and lungs from hamsters (filled bars) and mice (open bars) infected with virulent L. interrogans serovar Icterohaemorrhagiae strain Verdun. Kinetics are time points ranging from 6 h p.i. to day 4 p.i. in hamsters and to day 15 p.i. in mice (see details in Table 3). Results are expressed as relative normalized expression ratios using noninfected animals as calibrators. Values are means ± SEMs (n = 3 animals).