Table 1.

Immune-related response criteria

Complete response	Disappearance of all lesions in two consecutive observations at least 4 weeks apart
Partial response	≥50% decrease in tumor burden compared with baseline in two observations at least 4 weeks apart
Stable disease	<50% decrease in tumor burden compared with baseline and <25% increase in tumor burden compared with nadir
Progressive disease	≥25% increase in tumor burden compared with nadir in two consecutive observations at least 4 weeks apart
New lesions	Do not automatically define progression; incorporated into tumor burden