Table 2.
Classification of different α-helical AMPs according to their membrane permeabilization mechanisms
Pore-forming mechanism | Peptide | Origin | Reference |
Carpet-like (detergent-like) | Cecropins | Hyalophora cecropia | 47 |
PGLa | Xenopus laevis | 48 | |
Dermaseptins | Phyllomedusa spp. | 49 | |
Ovispirin | Ovis aries | 50 | |
Latarcins | Lachesana tarabaevi | 51 | |
RL-37 | Macaca mulatta | 52 | |
Toroidal (wormhole) | Mastoparan X | Vespa xanthoptera | 53 |
Magainin 2 | Xenopus laevis | 54, 55 | |
LL-37 | Homo sapiens | 52, 56 | |
Melittin | Xenopus laevis | 57 | |
Piscidin | Morone saxatilis | 58 | |
Barrel-Stave | Pardaxin | Pardarchirus marmoratus | 59 |
Alamethicin | Trichoderma viride | 60 | |
Amphotricin B | Streptomyces nodosus | 61 | |
Ceratotoxin | Ceratitis capitata | 62 |