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. 2011 Sep 14;40(2):541–552. doi: 10.1093/nar/gkr701

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — XIAP IRES initiation complexes are IRES dependent. (A) Secondary structure model of the XIAP IRES (54) with the introduced mutations within the IRES indicated. The UU sequence of the polypyrimidine tract was mutated to AA in the PPT mutant (indicated with a rectangle); the initiation codon AUG was replaced with AAC in the SC mutant (indicated with a circle). (B) Toeprinting analysis was carried out to determine the ability of PPT, capped PPT and SC XIAP IRES mutants to form initiation complexes in RRL pre-treated with GMP-PNP and ATP.