Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Sep 27;40(2):726–738. doi: 10.1093/nar/gkr748

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 5. — The roles of BRCA1 in promoting RAD51 recruitment induced by replication fork collapse are enhanced by ATR depletion. (A) BRCA1 and Rad51 colocalizes in response to replication fork stalling and collapsed. (B) The roles of BRCA1 in Rad51 recruitment upon replication fork stalling and collapse are differentially regulated by ATR depletion. Exponentially growing MCF7 cells were first infected with both of BRCA1sh and ATRsh. Forty-eight hours after infection, the cells treated with HU were fixed at indicated time points. Then the fixed cells were detected for RAD51 by immunostaining. The data are from three independent experiments. Y-axis represents the percentage cell with positive foci. Cells were scored positive when 10 nuclear foci were visible. Results are means from three independent experiments, with standard errors shown. P-values were calculated by Student's t-test (*P < 0.01).