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. 2011 Sep 19;40(2):581–593. doi: 10.1093/nar/gkr757

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Mediator is involved in telomere length regulation. (A) The telomere length of all 15 viable Mediator mutants was examined by telomere Southern blot. The telomere lengths of the tested strains were quantified and the changes of telomere length compared with wild-type strain were indicated at the bottom of the corresponding lanes. (B) Telomere length of double mutants of different modules was monitored as in (A). (C) Expression of genes encoding telomerase components in Mediator mutants was detected by qRT-PCR. Statistical analyses in this study were calculated using Student's t-test (*P < 0.05 and **P < 0.01). (D) Telomere length analysis of the Mediator mutants overexpressing TLC1 with the CEN plasmid pRS316-TLC1. V: vector (pRS316), T: Tlc1 (pRS316-TLC1). The telomere length changes indicated at the bottom denote the differences between the mean values of two clones with or without TLC1 overexpression respectively.