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. 2011 Sep 19;40(2):581–593. doi: 10.1093/nar/gkr757

Figure 2.

Figure 2.

Mediator tail module is required for telomere position effect and acts through Sir2. (A) Telomere position effect (TPE) of 14 Mediator mutants. Cells were grown in YPD and diluted to the same concentration. Five-fold serial dilutions of each strain were spotted to YC plates with or without 0.15% 5-FOA as indicated. (B) The expression of telomeric URA3 (TEL::URA3) reporter gene detected by qRT-PCR, and normalized to that of ACT1 gene. (C) TPE of Mediator single mutants and double mutants of Mediator and SIR2. (D) qRT-PCR results of expression of double mutants of Mediator and SIR2.