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. 2011 Sep 19;40(2):581–593. doi: 10.1093/nar/gkr757

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Mediator is associated with both modified and natural telomeres independently of Sir2 or Rap1. (A) Binding of 13Myc-tagged Mediator subunits on telomere m7L. The LEU1 locus serves as a negative control where little Mediator binds (48). (B) Binding of Mediator on native telomeres 3R and 6R. (C) Binding of Mediator on telomeres m7L, 3R and 6R in sir2Δ strains. (D) Telomeric binding of Mediator subunits Med2 and Med3 in RAP1 or rap1-2 strains at 23°C or 37°C were detected by ChIP assay. (E–G) ChIP results of Mediator binding in wild-type, med20Δ or med15Δ cells on telomeres m7L (E), 3R (F) and 6R (G).