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(a) Colour ramped N- to C-terminal (ramped blue to red) cartoon representation showing the secondary structure of Spd1. The following colours correspond to the secondary structure features in the text β1–β2 deep to light blue, β3–β5 turquoise to green, α1–α2 green to yellow, β6–β8 yellow to orange and β9–β12 light red to deep red. (b) Modelled surface of the WT Spd1 structure in the same orientation as (a), showing the position of the catalytic histidine His121 (red).
