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. 2012 Jan 15;23(2):324–336. doi: 10.1091/mbc.E11-09-0765

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© 2012 Revenu et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — The VEP^−/− mice have growth defects, but the morphology of their intestinal epithelium looks normal. (A) Picture of a triple KO VEP^−/− animal next to a WT animal of the same age. (B) Growth curves plotting the average weight of 35 triple heterozygotes (VEP^+/−), 16 villin/plastin-1 double KO (VP^−/−), and 35 triple KO (VEP^−/−) mice according to their age. Males and females were analyzed separately. (C and D) Histological sections of jejunum from WT and triple KO (VEP^−/−) animals. (C) H&E shows a hematoxilin and eosin staining (scale bar: 200 μm), phalloidin labels F-actin (scale bar: 100 μm). Immunostaining for ezrin, E-cadherin, and ZO-1 is shown. Scale bars: 100 μm; insets: 10 μm. (D) The global cellular organization of the cytoskeletal elements is presented. Microtubules and F-actin are revealed by immunostaining against α-tubulin (α-Tub., green) and phalloidin labeling (Phal., red). Cytokeratins are labeled with a pancytokeratin antibody (green); 4′,6-diamidino-2-phenylindole (DAPI) labels nuclei (blue). Scale bars: 10 μm.