Table 1. Conditional logistic regression analysis of the MS associated variants.
Conditional on | ||||||||
Unconditional | rs3135388 | |||||||
Spanish | SNP | Risk allele | F_A | F_U | P | OR | P cond | OR |
eQTL DRB5 | rs9270986 | A | 0.2451 | 0.1256 | 1.05E-22 | 2.392 | 0.117 | 1.396 |
eQTL DRB1 | rs9271100 | T | 0.3481 | 0.2279 | 1.24E-17 | 1.881 | 0.01306 | 1.275 |
DRB1*1501 | rs3135388 | G | 0.219 | 0.1031 | 1.96E-23 | 2.591 | NA | NA |
eQTL DQB1 | rs9272346 | G | 0.4455 | 0.3917 | 0.0003381 | 1.265 | 0.356 | 0.9341 |
F_A, Frequency of affected; F_U, Frequency of unaffected; NA, not applicable; P cond, P-value of logistic regression analysis conditioned on the respective SNP; OR, odds ratio; SNP, single-nucleotide polymorphism. The data from African American are from McElroy et al. [7].