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. 2012 Jan 13;7(1):e29647. doi: 10.1371/journal.pone.0029647

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Teng et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Intracellular accumulation of polyphenol compounds and their metabolites, (a₁) apigenin and metabolites, (a₂) resveratrol and metabolites, (a₃) emodin and metabolites, (a₄) chrysophanol and metabolites. Transport of glucuronides and sulphates from different directions in Caco-2 cells (nmol/L• mg • protein), (b₁) glucuronides from AP to BL, (b₂) sulphates from AP to BL, (b₃) glucuronides from BL to AP, (b₄) sulphates from BL to AP. The effect of different inhibitors (100 µM verapamil,100 µM cyclosporine A, 50 µM phloridzin) on the transport of polyphenol compounds in Caco-2 cells; (c₁) apigenin, (c₂) resveratrol, (c₃) emodin, (c₄) chrysophanol. (mean ± SD, n = 6).