Table 2.
Myocardial Metabolic and Function Variables
| Variable | HIV-/MC- (n = 22) | HIV-/MC+ (n = 9) | HIV+/MC- (n = 15) | HIV+/MC+ (n = 23) |
|---|---|---|---|---|
| MVO2 (μmol/g/min) | 4.3 ± 1.0 | 4.5 ± 1.3 | 3.9 ± 1.1 | 4.3 ± 1.1 |
| MBF (ml/g/min) | 0.97 ± 0.19 | 1.06 ± 0.22 | 0.92 ± 0.26 | 0.97 ± 0.29 |
| GLUT (nmol/g/min) | 242 ± 141 | 139 ± 71 | 184 ± 135 | 113 ± 66 |
| Glycolysis (nmol/g/min) | 69 ± 54 | 40 ± 30 | 80 ± 89 | 81 ± 39 |
| Glycogen formation (nmol/g/min) | 147 ± 82 | 127 ± 57 | 118 ± 90 | 35 ± 34 |
| Lactate production (nmol/g/min) | 10 ± 11 | 5 ± 7 | 18 ± 35 | 6 ± 9 |
| Glucose oxidation (nmol/g/min) | 62 ± 43 | 34 ± 23 | 70 ± 67 | 33 ± 33 |
| EF Total (%) | 42 ± 8 | 38 ± 6* | 49 ± 19 | 37 ± 8¶ |
| FAOX (nmol/g/min) | 133 ± 56 | 145 ± 44 | 115 ± 47 | 97 ± 38 |
| FAOX/MVO2 | 30 ± 13 | 34 ± 11 | 32 ± 15 | 23 ± 9 |
| FAEST (nmol/g/min) | 19 ± 20 | 10 ± 11 | 35 ± 28 | 24 ± 23 |
| FAUT (nmol/g/min) | 110 ± 89 | 155 ± 43 | 149 ± 55 | 122 ± 40 |
| HR (bpm) | 57 ± 7 | 72 ± 10† | 60 ± 14 | 62 ± 10 |
| SBP (mm/Hg) | 116 ± 12 | 134 ± 1† | 125 ± 20 | 127 ± 14 |
| DBP (mm/Hg) | 63 ± 10 | 73 ± 9 | 73 ± 11 | 74 ± 9 |
| RPP (arbitrary units) | 6269 ± 1737 | 9684 ± 1864‡ | 7488 ± 1775 | 7896 ± 1666† |
| LVM MM (g) | 185 ± 29 | 230 ± 42§ | 185 ± 40 | 189 ± 41 |
| EDV (mL) | 125 ± 23 | 129 ± 18 | 101 ± 25 | 110 ± 24 |
| ESV (mL) | 52 ± 12 | 53 ± 13 | 39 ± 10 | 44 ± 13 |
| EF (%) | 58 ± 4 | 59 ± 6 | 61 ± 5 | 60 ± 8 |
| LVET (ms) | 319 ± 25 | 272 ± 17‡ | 313 ± 37 | 297 ± 29 |
| Sm (cm/s) | 8 ± 1 | 8 ± 2 | 8 ± 1 | 8 ± 1 |
| E wave (cm/s) | 74 ± 15 | 59 ± 21 | 71 ± 14 | 66 ± 16 |
| E/A ratio | 2.1 ± 0.6 | 1.5 ± 0.5 | 1.7 ± 0.6 | 1.4 ± 0.5 |
| Em (cm/s) | 17.2 ± 1.9 | 12.1 ± 2.4§ | 13.9 ± 1.7 | 12.8 ± 2.0† |
| DT (ms) | 178 ± 29 | 197 ± 21 | 198 ± 35 | 202 ± 48 |
| IVRT (ms) | 80 ± 13 | 74 ± 8 | 79 ± 8 | 80 ± 7 |
Data expressed as mean ± SD. MVO2: myocardial oxygen consumption, MBF: myocardial blood flow, GLUT: myocardial glucose utilization, EFTotal: myocardial fatty acid extraction fraction total, FAOX: fatty acid oxidation, FAEST: fatty acid esterification, FAUT: fatty acid utilization, LVM = left ventricular mass, LVMI: left ventricular mass index, EDV: end diastolic volume, ESV: end systolic volume, EF: ejection fraction, LVET: left ventricular ejection time, Em: average myocardial relaxation velocity during early diastole measured at the lateral wall and septal bases, DT: deceleration time, and IVRT: isovolumic contraction time. *: p < 0.05 vs. HIV-/MC- and HIV-/MC+, †: p < 0.05 vs. HIV-/MC-, ‡: p < 0.05 vs. remaining groups, §: p < 0.05 vs. HIV-/MC- and HIV+/MC-, ¶: p < 0.05 vs. HIV+/MC-.