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Overview of tetrahydrofolate metabolism. DHF: dihydrofolate; THF: tetahydrofolate (glu)1; H-THF: formyl-tetrahydrofolate; CH-THF: 5,10-methenyltetrahydrofolate; CH2-THF: 5,10-methylenetetrahydrofolate; CH3-THF: 5-methyltetrahydrofolate; Met: methionine; Ser: serine; Gly: glycine; SAM: S-adenosylmethionine; Td: thymidine; Pur: Purines; fMet: N-methionyl-tRNAfmet.
