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. 2011 Nov 28;12:583. doi: 10.1186/1471-2164-12-583

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Copyright ©2011 Sangurdekar et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schematics of a pyrimidine salvage pathway. Model of deoxyribose nucleotide salvage pathway. Double dashed line indicates block in a pathway due to gene deletion or in case of pathway 9 (dUMP → dTMP), block in pathway due to starvation of cells for essential cofactor tetrahydrofolate (not shown) by TMP treatment. Thymine and thymidine represent external metabolites transported from the media. Genes associated with pathways: 1 - cdd; 2 - deoA; 3 - deoB; 4 - deoC; 5 - tdk; 6 - yjjG; 7 - tdk; 8 - nudI/dut; 9 - thyA; 10 - tmk; 11 - ndk. Abbreviations: dCyt: deoxycytidine; dUrd.: deoxyuridine; Ura. - uracil; dR1P - deoxyribose-1-phosphate; dR5P: deoxyribose-5-phosphate; G3P/acet.: glyceraldehyde-3-phophate/acetaldehyde; Thd - thymidine (external); Thy - thymine (external).