. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Hum Genet. 2011 Aug 5;131(2):289–299. doi: 10.1007/s00439-011-1076-8

Table 4.

Relationship between FcγRIIA-131H/R and FcγRIIIB-NA1/NA2 haplotypes and susceptibility to SMA in children with acute malaria.

	SMA (Hb<6.0 g/dL)

Haplotype	OR	95%CI	P
FcγRIIA-131H/FcγRIIIB-NA1	0.83	0.72 – 1.06	0.088
FcγRIIA-131H/FcγRIIIB-NA2	0.76	0.53 – 1.09	0.140
FcγRIIA-131R/FcγRIIIB-NA1	0.92	0.72 – 1.11	0.386
FcγRIIA-131R/FcγRIIIB-NA2	1.44	0.97 – 2.13	0.071

Children with acute malaria (n=528) were categorized according to a modified definition of SMA based on age- and geographically-matched Hb concentrations (i.e., Hb<6.0 g/dL, with any density parasitemia) (McElroy et al. 1999). Odds Ratios (OR) and 95% confidence intervals (CI) were determined using multivariate logistic regression controlling for age, gender, HIV-1 status, bacteremia, sickle cell trait (HbAS) and G6PD deficiency. The reference groups in the multivariate logistic regression analyses were those without the respective haplotypes.