Table 2.

Associations between modifiable risk factor combinations and overall dementia (n=3,468)

Low-Risk Subgroup	% of men	No. of cases	Odds Ratio (95% CI) *
One low-risk factor†	63.6	140	0.72 (0.50–1.03)
Nonsmoking
Two low-risk factors‡	25.7	53	0.66 (0.44–0.99)
Nonsmoking
Diet score in top 40%
Three low-risk factors§	17.0	33	0.57 (0.35–0.94)
Nonsmoking
Diet score in top 40%
BMI <25.0 kg/m2
Four low-risk factors	7.2	11	0.36 (0.15–0.84)
Nonsmoking
Diet score in top 40%
BMI <25.0 kg/m2
High physical activity

^*All models adjust for age, years of education, APOE e4 status, the interaction between APOE e4 status and the low-risk subgroup, and childhood years spent in Japan.

^†Model also adjusts for diet score, BMI, and physical activity.

^‡Model also adjusts for BMI and physical activity.

^§Model also adjusts for physical activity.