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In vitro stimulation of mouse lung by SPD-MAA adducted protein. Lung slices were treated with SPD or SPD-MAA in the presence or absence of Rö 31-8220 for 24 hr and media supernatants assayed for keratinocyte chemokine (KC). The significant (P<0.01) increase in KC release in response to SPD-MAA was inhibited by a 1 hr pretreatment with Rö 31-8220.
