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Schematic of the inhibition of iNOS-dependent innate immune response. H. pylori upregulates Arg2 which reduces L-Arg in the cytosol that is needed for iNOS translation, ODC converts L-ornithine into the polyamines putrescine, spermidine, and spermine, and spermine inhibits L-Arg uptake and thus iNOS protein translation and NO production. Inhibition of NO synthesis leads to decreased killing of H. pylori and thus its survival in the gastric niche
