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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Adv Drug Deliv Rev. 2011 Sep 6;64(2):200–216. doi: 10.1016/j.addr.2011.08.006

Fig. 16.

Fig. 16

(a) Preparation of AuNPs co-functionalized with antisense oligonucleotide (to GAPDH: glyceraldehyde phosphate dehydrogenase) and peptide (Tat or NLS sequences). Pre-addition of salt helps in stabilizing the NPs. (b) Oligonucleotide and peptide loading as a function of solution stoichiometry determined by fluorescent labeling. (c) Relative decrease in GAPDH expression in HeLa cells. β-Tubulin was used as a loading control and for subsequent normalization of GAPDH knockdown. Adapted with permission from [109].