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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Adv Drug Deliv Rev. 2011 Sep 6;64(2):200–216. doi: 10.1016/j.addr.2011.08.006

Fig. 18.

Fig. 18

(a) Change in relative fluorescence intensity of GeneFinderTM (a highly sensitive DNA detection dye) at 523 nm as a measure of stability of lipid/DNA and lipid-AuNP/DNA complexes. While bound to DNA, the dye showed higher fluorescence revealing that DDAB-AuNP was stable in FBS (fetal bovine serum) or SDS. (b) Cell viability of DDAB and DDAB-AuNP measured by MTT assay after incubation for 26 hrs. (c) Transfection of PGL3 plasmid DNA inside 293 cells using naked DNA, DNA/DODAB, and DNA/DODAB-AuNP complexes. (d) Transfection efficiency quantified by the percentage of fluorescent cells by flow cytometry. (e) Schematic of transport process of DODAB-AuNPs/DNA complexes in the DMSO and NCZ pre-treated cells. Adapted with permission from [135,136,138].