Table 5.

Anti-HIV Activity (EC₅₀) and Average Cytotoxicity (CC₅₀), μM, of Catechol Diether Derivatives and Reference NNRTIs for WT and Viral Variants.

Compd	EC50			CC50
	WT	Y181C	K103N/Y181C
20	0.14	21	2.2	77
22	0.090	6.7	1.2	32
25	0.014	0.52	1.7	>100
26	0.013	0.62	1.7	13
27	0.017	0.24	0.57	21
31	0.043	0.92	2.8	59
32	0.020	0.80	>43	>61
40	0.015	0.98	8.0	>90
41	0.005	0.37	1.6	22
42	0.000055	0.049	0.22	10
43	0.0032	0.15	0.90	48
44	0.00032	0.016	0.085	45
45	0.020	2.8	ND	30
nevirapine	0.11	>100	>100	>100
nevirapinea	0.081	>10	>10
efavirenz	0.002	0.010	0.030	15
efavirenza	0.0014	0.002	0.037
etravirine	0.001	0.008	0.005	11
etravirinea	0.001	0.007	0.004
rilpivirine	0.00067	0.00065	0.002	>1
rilpivirinea	0.0004	0.0013	0.001	8

^aLiterature data; see ref. 28.