Figure 1.

Effect of paclitaxel (Taxol) on blood pressure and renal functions of rats with remnant (Rem) kidney. (A) Systolic blood pressure; (B) 24 h urinary protein excretion; (C) serum creatinine; (D) protein : creatinine ratio; (E) creatinine clearance; (F) BUN. All the renal functional parameters were almost normalized with Taxol treatment in the Rem group; however, the blood pressure was unaffected by Taxol treatment. Data represent mean ± SEM for groups of 12 rats treated with Taxol. ^Δp < 0.05 versus Sham or Sham + Taxol groups; ^#p < 0.05 versus Rem group (n = 12)