Figure 1.

Complexity in lncRNA-chromatin modifying complex interactions. Chromatin remodelling complexes are capable of interacting with multiple lncRNAs. Similarly, lncRNAs may interact with more than one protein complex. A to D: Protein lncRNA interactions may result in conformational changes, which may help distinguish target specificity. E: Chromatin remodelling complexes F: Hypothetical nucleus depicting lncRNA–protein complexes and their silencing compartments. Xist domain is shown at the nuclear periphery with inactive X chromatin. Airn and Kcnq1ot1 are shown to silence specific genes on their respective imprinted loci while HOTAIR is seen to target loci genome wide in concert with different protein complexes. Note that mouse Hotair does not participate in silencing the HoxD cluster and is not reported to interact with chromatin remodelling complexes [55]. Human HOTAIR is depicted in this schema.