Table 1. Clinical Characteristics of Patients with HF in Olmsted County*.
| N missing |
Total (N=1049) |
Tertile 1 PASP<41 mmHg (N=343) |
Tertile 2 PASP=41- 54 mmHg (N=370) |
Tertile 3 PASP>54 mmHg (N=336 |
p value (trend) |
|
|---|---|---|---|---|---|---|
| Age, mean ±SD, y | -- | 75.6±13.3 | 73.4±13.4 | 76.2±13.0 | 77.1±13.3 | <0.001 |
| Men | -- | 517 (49.3) | 188 (54.8) | 172 (46.5) | 157 (46.7) | 0.035 |
| Cardiovascular risk factors | ||||||
| Hypertension | -- | 897 (85.5) | 294 (85.7) | 311 (84.1) | 292 (86.9) | 0.664 |
| Current smoker | -- | 97 (9.3) | 37 (10.8) | 32 (8.7) | 28 (8.3) | 0.269 |
| Diabetes mellitus | -- | 347 (33.1) | 113 (32.9) | 110 (29.7) | 124 (36.9) | 0.278 |
| Hyperlipidemia | -- | 783 (74.6) | 274 (79.9) | 269 (72.7) | 240 (71.4) | 0.011 |
| BMI, median (Q1- Q3) |
-- | 27.5 (24-32) | 28.4 (25-32) | 27.5 (24-31) | 26.5 (23-31) | 0.015 |
| Comorbidities | ||||||
| Prior MI | -- | 251 (23.9) | 83 (24.2) | 86 (23.2) | 82 (24.4) | 0.952 |
| COPD | -- | 293 (27.9) | 89 (26.0) | 110 (29.7) | 94 (28.0) | 0.552 |
| Estimated glomerular filtration rate, median (Q1-Q3), mL/min per 1.73 m2 |
203 | 52.2 (38-64) | 54.2 (44-67) | 52.1 (39-64) | 48.1 (34-59) | <0.001 |
| Anemia | 4 | 537 (51.4) | 146 (42.7) | 189 (51.4) | 202 (60.3) | <0.001 |
| Atrial fibrillation/flutter |
1 | 379 (36.2) | 98 (28.6) | 155 (42) | 126 (37.5) | 0.015 |
| Comorbidity index | -- | 0.096 | ||||
| 0 | 156 (14.9) | 58 (16.9) | 52 (14.1) | 46 (13.7) | ||
| 1-2 | 321 (30.6) | 106 (30.9) | 121 (32.7) | 94 (28.0) | ||
| ≥3 | 572 (54.5) | 179 (52.2) | 197 (53.2) | 196 (58.3) | ||
| HF characteristics and severity indices | ||||||
| NYHA class | -- | 0.001 | ||||
| I | 63 (6.0) | 29 (8.5) | 16 (4.3) | 18 (5.4) | ||
| II or III | 647 (61.7) | 222 (64.7) | 234 (63.2) | 191 (56.9) | ||
| IV | 339 (32.3) | 92 (26.8) | 120 (32.4) | 127 (37.8) | ||
| BNP, pg/mL, median (Q1-Q3) |
154 | 426 (209- 836) |
306 (133-566) | 417 (233- 736) |
675 (320-1170) | <0.001 |
*
Data are presented as N (%), unless otherwise specified.
BMI=body mass index; BNP= brain natriuretic peptide; COPD=chronic obstructive pulmonary disease; HF=heart failure; MI=myocardial infarction; NYHA= New York Heart Association; PASP=pulmonary artery systolic pressure; Q1=25th percentile; Q3=75th percentile.