Figure 1.

IL-22TG mice are resistant to cerulein-induced acute pancreatitis. WT, IL-22KO, and IL-22TG mice were treated seven times with cerulein or PBS injections to induce acute pancreatitis. Mice were sacrificed one hour after the last injection. The ratio of the pancreas/body weight, serum levels of IL-22, and amylase and lipase levels were measured (A). Representative H&E staining, TUNEL staining, and MPO staining are shown in the left panel of (B). The pathology score and the number of TUNEL⁺ and MPO⁺ cells are summarized in the right panel of (B). *** P < 0.001 compared to cerulein-treated WT mice. Data are representative of three different experiments, 5~7 mice in each group. In panel A, UD: undetectable.