Figure 2.

IL-22TG mice are resistant to cerulein-induced chronic pancreatitis. WT and IL-22TG mice received seven cerulein or PBS injections weekly for four weeks to induce chronic pancreatitis. Mice were sacrificed one hour after the last injection. Representative H&E staining, TUNEL staining, and MPO staining are shown (A). Serum levels of amylase and lipase were measured. The pathology score and the number of TUNEL⁺ and MPO⁺ cells are summarized (B). ***P<0.001 compared to cerulein-treated WT mice. Data are representative of three different experiments, 5~7 mice in each group.