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Upregulation of Bcl-2 and Bcl-XL, which bind Beclin-1, was associated reduced autophagosome formation in the pancreases of cerulein-treated IL-22TG mice. (A) Western blot analyses of pancreatic protein extracts from WT and IL-22TG mice. (B) Immunoprecipitation analyses of the interaction of Beclin-1 with Bcl-2 family proteins. (C) Scheme of the mechanisms underlying IL-22 inhibition of autophagy and pancreatitis. Data are representative of three different experiments.
