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. 2011 Dec 27;109(2):564–569. doi: 10.1073/pnas.1117665109

Fig. 3.

Fig. 3.

hAAT alters the ratio of mature donor Teff to Treg cells. C3H.SW mice were irradiated and transplanted with either allogeneic B6GFP+Foxp3 knock-in donor. The recipient animals received either hAAT or rapamycin or the control vehicle as above. Expansion of mature donor (CD45.2+CD45.1−CD229.1−GFP−) CD4 and CD8+ effectors and the mature donor (CD45.1−CD45.2+CD229.1−GFP+) Tregs was analyzed in the peripheral blood on day +21 and day +28 for the ratio of CD8+ to CD4+ FoxP3+ T-cell absolute numbers of mature donor-derived (CD45.2+CD45.1−CD229.1+). Each point represents one individual mouse (n = 2–5/group). (A) CD4+:Treg ratio on day +21, vehicle vs. hAAT; P = 0.037. (B) CD8+:Treg ratio on day +21, vehicle vs. hAAT, P = 0.022. (C) CD4+:Treg ratio on day +28, vehicle vs. hAAT; P = 0.0223. (D) CD8+:Treg ratio on day +28, vehicle vs. hAAT; P = 0.0127.