Fig. 1.
(A) Mean and SE of the centrality scores of obesity-associated enzymes vs. all other enzymes in the network. Obesity-associated enzymes are further divided into enzymes that are enriched or depleted in obese microbiomes. (B) Proportion of enzymes that are associated with obesity (main plot) and IBD (Inset) within three equally populated centrality-based network tiers. Each concentrical pie chart depicts the percent of enzymes within a specific centrality tier that are classified as enriched or depleted. Enzymes associated with obesity or IBD are found in significantly higher proportions in the peripheral tier (P < 5.6 × 10−6 [obesity], P < 4.8 × 10−5 [IBD]; Hypergeometric enrichment test). This result still holds considering alternative or stricter criteria for association with the host state (SI Appendix).