Skip to main content
. 2011 Dec 19;109(2):582–587. doi: 10.1073/pnas.1106750109

Fig. 1.

Fig. 1.

Circadian gating of murine cytokine responses to LPS. (A) Serum cytokines were quantified 4 h after i.p. LPS administration at either CT0 or CT12. IL-6, IL-12(p40), CCL5, CXCL1, and CCL2 (but not TNF-α) showed significantly higher levels after CT12 challenge vs. CT0 (n = 7–9, two-way ANOVA, post hoc Bonferroni). (B) mRNA was isolated from PECs harvested 30 min after LPS treatment at either CT0 or CT12. Levels of cytokine mRNA were quantified (relative to β-actin) and are presented in relation to expression levels in PECs harvested at CT0 from vehicle-treated mice (n = 6–7, t test).