Figure 1.

Induction of bradycardia-dependence of EAD by hypokalaemia or H₂O₂. A patch-clamped rabbit myocyte was superfused with Tyrode's solution containing normal 5.4 mmol/L K⁺ (A), reduced 2.7 mmol/L K⁺ (B), or 1.0 mmol/L H₂O₂ (in normal 5.4 mmol/L K⁺) (C). Both hypokalaemia and oxidative stress with H₂O₂ caused EADs (*) at long pacing cycle lengths (PCL) but not at PCL 1 s.