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. 2011 Nov 2;93(2):242–251. doi: 10.1093/cvr/cvr292

Figure 5.

Figure 5

Effects of Ef vs. Gf on EAD threshold. Threshold for EAD formation (see text) of the myofibroblast-coupled state was compared with that of the control myofibroblast-uncoupled state. (A) Coupling a passive myofibroblast model to a Luo-Rudy 1 myocyte AP model to simulate the same eight coupling combinations tested experimentally in Table 1 lowered EAD threshold much more prominently for high Ef–high Gf (Ef −25 mV/Gf 123 pS) cases than for low Ef–low Gf (Ef −50 mV/Gf 26 pS) cases. (B) When Ef was kept low at −50 mV for all eight parameter combinations, Gf had little effect or increased EAD threshold. (C) When Ef was held high at −25 mV for all eight parameter combinations, Gf decreased EAD threshold in all cases, indicating that high Ef is more important than high Gf at lowering EAD threshold. Numbers indicate the per cent change in EAD threshold.