Table IV.

Studies on the association between catechol-O-methyltransferase (COMT) genotype and BPSD in AD (positive results in bold)

Reference	No. of participants	Effect of COMT genotype on BPSD
Borroni et al., 2004 [95]	181	HH genotype and H allele increase risk for psychosis
Sweet et al., 2005 [96]	373	A four-locus haplotype increases the risk for psychosis
Borroni et al., 2006 [44]	234	HH genotype and H allele increase risk for psychosis
Borroni et al., 2006 [45]	232	HH genotype and H allele decrease risk for “frontal” endophenotype and increase risk for hallucinations
Borroni et al., 2007 [97]	246	HH genotype and H allele increase risk for psychosis. Alleles at four loci (haplotype) interact to influence psychosis risk