Table I.
Effects of high fructose diet alone and in combination with aliskiren on plasma glucose, insulin, triglycerides and total cholesterol
| Group | N | Day 0 | Day 28 | Day 56 |
|---|---|---|---|---|
| Glucose [mmol/l] | ||||
| Con | 6 | 6.45 ±0.81 | 6.33 ±0.47 | 6.90 ±0.20 |
| Fru | 6 | 6.46 ±0.79 | 10.54 ±0.89*# | 11.86 ±1.47*# |
| FruA | 6 | 6.42 ±0.68 | 6.49 ±0.22 | 7.07 ±0.45 |
| FruB | 6 | 6.31 ±0.45 | 10.67 ±1.40*# | 6.74 ±0.41 |
| Insulin [pmol/l] | ||||
| Con | 6 | 161.6 ±20.8 | 155.6 ±19.6 | 148.4 ±26.7 |
| Fru | 6 | 153.1 ±30.0 | 310.0 ±32.2*# | 289.6 ±22.5*# |
| FruA | 6 | 150.8 ±25.6 | 149.0 ± 27.7 | 161.6 ±24.6 |
| FruB | 6 | 159.2 ±20.5 | 301.6 ±36.3*# | 160.3 ±23.0 |
| Triglycerides [mmol/l] | ||||
| Con | 6 | 1.56 ±0.09 | 1.60 ±0.10 | 1.55 ±0.08 |
| Fru | 6 | 1.60 ±0.15 | 3.13 ±0.23*# | 3.34 ±0.25*# |
| FruA | 6 | 1.55 ±0.12 | 1.59 ±0.09 | 1.72 ±0.21 |
| FruB | 6 | 1.50 ±0.09 | 3.15 ±0.17*# | 1.68 ±0.13 |
| Total cholesterol [mmol/l] | ||||
| Con | 6 | 2.21 ±0.31 | 2.27 ±0.14 | 2.20 ±0.13 |
| Fru | 6 | 2.25 ±0.17 | 3.24 ±0.14*# | 3.30 ±0.13*# |
| FruA | 6 | 2.42 ±0.15 | 2.38 ±0.23 | 2.31 ±0.15 |
| FruB | 6 | 2.33 ±0.11 | 3.16 ±0.20*# | 2.42 ±0.21 |
Con indicates controlrats with normal chow diet, Fru – fructose-fed diet, FruA – fructose-fed diet with concurrent aliskiren administration, FruB – fructose-fed diet and further aliskiren administration after 4 weeks of fructose-fed diet;
*
p < 0.05 vs. day 0,
#p < 0.05 vs. control group