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Beclin1 CCD dimerizes in solution. Beclin1 CCD (A) and Beclin1 BH3-CCD (B) were analyzed by sedimentation equilibrium and fitted to an ideal single-species model. Representative fits for each protein are shown. C, Beclin1 CCD and Beclin1 BH3-CCD were also analyzed by sedimentation velocity and fitted to the c(S) and c(M) size-distribution functions. The c(M) distribution is shown for both proteins.
